PROSPECT provides clinicians with supporting arguments for and against the use of various interventions in postoperative pain based on published evidence and expert opinion. Clinicians must make judgements based upon the clinical circumstances and local regulations. At all times, local prescribing information for the drugs referred to must be consulted.
GoRs are assigned according to the overall LoE on which the recommendations are based, which is determined by the quality and source of evidence: Relationship between quality of the study and levels of evidence (LoE) and grades of recommendation.
Oncological breast surgery (hereafter, ‘breast surgery’) is associated with significant acute and chronic postoperative pain (Vadivelu 2008). A systematic review was performed by the PROSPECT collaboration in 2006 (archived on the PROSPECT website: Non-cosmetic Breast Surgery 2006). However, several new analgesic regimens, particularly regional analgesic techniques have been introduced since (Elsharkawy 2018). An updated systematic review on analgesic interventions dedicated to breast cancer was required.