Topics for Future Research - ESRA
View all Procedures

Laparoscopic Cholecystectomy 2005

Topics for Future Research


In certain circumstances, recommendations for a type of treatment cannot be made due to limited or conflicting evidence. Areas which have been identified as requiring further investigation in the future are as follows:

  • Time of drug administration, e.g.:
    • pre- versus post-incisional administration of various agents, such as conventional NSAIDs, COX-2-selective inhibitors, paracetamol
    • IP LA instillation at the start of surgery versus administration at the end of surgery
  • IV LA infusion
  • Alpha-2-adrenergic receptor agonists
  • Dextromethorphan
  • Ketamine
  • Interpleural local anaesthetic
  • Intra-operative fluid management
  • Postoperative PCA IP local anaesthetic
  • Humidified and/or warmed pneumoperitoneum
  • Nitrous oxide pneumoperitoneum
  • Total size of trocar incision
  • Radially expanding trocars
  • Surgeon’s position
  • Subhepatic drains
  • Aspiration of the pneumoperitoneum gas